Warfarin Resistance Due to Azathioprine

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Estramustine/Oral Calcium Products

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Products that contain calcium may prevent your body from absorbing your estramustine.

What might happen:

Your estramustine may not work as well.

What you should do about this interaction:

Do not take products containing calcium at the same time as your estramustine. Try to avoid taking them for 3 hours before and after your estramustine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Estracyt (estramustine phosphate) UK summary of product characteristics. Pharmacia Limited June 3, 2004.

2.Emcyt (estramustine phosphate sodium) US prescribing information. Pharmacia March, 2003.

3.Sandocal (calcium carbonate) Australian prescribing information. Novartis Consumer Health July, 1998.

4.Gunnarsson PO, Davidsson T, Andersson SB, Backman C, Johansson SA. Impairment of estramustine phosphate absorption by concurrent intake of milk and food. Eur J Clin Pharmacol 1990;38(2):189-93.
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